Ireland Penelope Jane, Ware Robert S, Donaghey Samantha, McGill James, Zankl Andreas, Pacey Verity, Ault Jenny, Savarirayan Ravi, Sillence David, Thompson Elizabeth, Townshend Sharron, Johnston Leanne M
Queensland Paediatric Rehabilitation Service, Royal Children's Hospital, Brisbane, Queensland, Australia.
J Paediatr Child Health. 2013 Feb;49(2):E122-7. doi: 10.1111/jpc.12078. Epub 2013 Jan 22.
This study aimed to investigate whether height, weight, head circumference and/or relationships between these factors are associated with gross motor milestone acquisition in children with achondroplasia.
Population-based data regarding timing of major gross motor milestones up to 5 years were correlated with height, weight and head circumference at birth and 12 months in 48 children with achondroplasia born in Australia and New Zealand between 2000 and 2009.
Although as a group children with achondroplasia showed delayed gross motor skill acquisition, within group differences in height, weight or head circumference did not appear to influence timing of gross motor skills before 5 years. The exception was lie to sit transitioning, which appears likely to occur earlier if the child is taller and heavier at 12 months, and later if the child has significant head-to-body disproportion.
This is the first study to investigate the relationship between common musculoskeletal impairments associated with achondroplasia and timing of gross motor achievement. Identification of the musculoskeletal factors that exacerbate delays in transitioning from lying to sitting will assist clinicians to provide more proactive assessment, advice and intervention regarding motor skill acquisition for this population.
本研究旨在调查身高、体重、头围以及这些因素之间的关系是否与软骨发育不全患儿的粗大运动里程碑获得情况相关。
对2000年至2009年在澳大利亚和新西兰出生的48例软骨发育不全患儿出生时及12个月时的身高、体重和头围数据，与5岁前主要粗大运动里程碑的达成时间进行了基于人群的数据关联分析。
尽管作为一个群体，软骨发育不全患儿的粗大运动技能获得延迟，但在5岁前，组内身高、体重或头围的差异似乎并未影响粗大运动技能的达成时间。例外情况是从躺到坐的转换，如果患儿在12个月时更高更重，则可能更早发生；如果患儿头身比例严重失调，则可能更晚发生。
这是第一项研究软骨发育不全相关常见肌肉骨骼损伤与粗大运动成就达成时间之间关系的研究。识别出加剧从躺到坐转换延迟的肌肉骨骼因素，将有助于临床医生对该人群的运动技能获得情况进行更积极主动的评估、建议和干预。
