Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Molecules. 2013 Jan 21;18(1):1262-9. doi: 10.3390/molecules18011262.
A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1-4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
从水杨梅的全株部分分离得到一个新的乌苏烷型三萜，3β-羟基-乌苏-30-p-Z-羟基肉桂酰氧基-12-烯-28-酸（1），以及三个已知的三萜，3β-羟基-乌苏-30-p-E-羟基肉桂酰氧基-12-烯-28-酸（2）、2α,3β,19α-三羟基乌苏-12-烯-28-酸（3）和熊果酸（4），四个已知的木脂素，松脂醇（5）、9α-羟基松脂醇（6）、（+）-medioresinol（7）和（+）-kobusin（8），以及两个甾体，β-谷甾醇（9）和胡萝卜苷（10）。通过光谱数据分析，结合文献数据比较，确定了它们的结构。对化合物 1-4 进行了 11β-羟甾醇脱氢酶 1（11β-HSD1）抑制活性评价。
