Shao Meng, Wang Ying, Huang Xiao-Jun, Fan Chun-Lin, Zhang Qing-Wen, Zhang Xiao-Qi, Ye Wen-Cai
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
J Asian Nat Prod Res. 2012;14(4):348-54. doi: 10.1080/10286020.2011.653964.
Four new triterpenoids, psiguanins A-D (1-4), along with 13 known ones (5-17), were isolated from the leaves of Psidium guajava. The structures of new compounds were determined as 2α,3β-dihydroxy-taraxer-20-en-28-oic acid (1), 2α,3β,12α,13β-tetrahydroxy-urs-28-oic acid (2), 2α,3β,12β,13β-tetrahydroxy-urs-28-oic acid (3), and 2α,3β,12β,13α-tetrahydroxy-urs-28-oic acid (4), respectively, on the basis of comprehensive spectroscopic methods and molecular modeling calculation. Among them, compound 4 was characterized as an unusual ursane-type triterpenoid with cis-fused C/D ring system.
从番石榴叶中分离出4个新的三萜类化合物，即番石榴苷A-D（1-4），以及13个已知化合物（5-17）。通过综合光谱方法和分子模型计算，分别确定新化合物的结构为2α,3β-二羟基蒲公英赛-20-烯-28-酸（1）、2α,3β,12α,13β-四羟基乌苏-28-酸（2）、2α,3β,12β,13β-四羟基乌苏-28-酸（3）和2α,3β,12β,13α-四羟基乌苏-28-酸（4）。其中，化合物4被鉴定为具有顺式稠合C/D环系统的罕见乌苏烷型三萜类化合物。
