Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET, National Academy of Medicine. Pacheco de Melo 3081 (1425), Buenos Aires, Argentina.
Viruses. 2013 Jan 21;5(1):340-51. doi: 10.3390/v5010340.
Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
沙粒病毒属引起的病毒性出血热（VHF）是一种以发热、头痛、全身不适、细胞免疫功能受损、最终神经受累和止血功能改变为特征的急性疾病，这些改变可能最终导致休克和死亡。出血的原因仍不清楚。然而，人们普遍认为，这些原因在某种程度上与止血功能障碍、内皮细胞功能障碍以及血小板计数或功能低下有关。本文介绍了沙粒病毒属引起的病毒性出血热中血液学改变的最新知识，包括潜在发病机制的新方面。
