Lönnerdal B, Chen C L
Department of Nutrition, University of California, Davis.
Acta Paediatr Scand. 1990 Mar;79(3):266-73. doi: 10.1111/j.1651-2227.1990.tb11455.x.
Infants, that had been formula-fed from birth, were fed follow-up formula with 1.5, 2.2 or 2.9 g protein/dl together with 25 g of cereal/day as supplemental food, or formula only (15 g/dl). Formulas were started at 4 months of age and daily intake, anthropometric measurements and plasma samples taken at 5, 6 and 7 months. Protein intake was 2.0, 3.0 and 3.7 g/kg/d, respectively. Growth data were similar for all groups, as were hemoglobin and serum protein values. BUN values for the group fed only formula with 1.5 g protein/dl were lower than for the group fed the same formula with cereals and the other groups. Plasma amino acids were not affected by the addition of the small amount of cereals to the formula with 1.5 g protein/dl, but significantly higher levels of valine, leucine and histidine were found at 7 months for infants fed the two higher protein levels. The highest protein level also appeared to have a negative effect on plasma zinc levels. These results suggest that a protein level of 1.5 g/dl in follow-up formula (2.0 g/kg/d) is adequate during 4 to 7 months of age and that higher protein levels may be excessive.
从出生就采用配方奶喂养的婴儿，分别喂食蛋白质含量为1.5、2.2或2.9g/dl的后续配方奶，并搭配每天25g谷物作为补充食物，或仅喂食配方奶（15g/dl）。配方奶从4个月龄开始喂食，在5、6和7个月时记录每日摄入量、进行人体测量并采集血浆样本。蛋白质摄入量分别为2.0、3.0和3.7g/kg/d。所有组的生长数据相似，血红蛋白和血清蛋白值也相似。仅喂食蛋白质含量为1.5g/dl配方奶组的尿素氮（BUN）值低于喂食添加谷物的相同配方奶组和其他组。对于蛋白质含量为1.5g/dl的配方奶，添加少量谷物对血浆氨基酸没有影响，但对于喂食两种较高蛋白质水平的婴儿，在7个月时缬氨酸、亮氨酸和组氨酸水平显著更高。最高蛋白质水平似乎也对血浆锌水平有负面影响。这些结果表明，后续配方奶中蛋白质含量为1.5g/dl（2.0g/kg/d）在4至7个月龄时是足够的，更高的蛋白质水平可能过高。
