*Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL †Konan Medical USA, Irvine, CA.
J Glaucoma. 2014 Sep;23(7):419-23. doi: 10.1097/IJG.0b013e31827b1522.
To evaluate the effectiveness of a new binocular infrared computerized pupillometer in the quantitative measurement of the relative afferent pupillary response in patients with glaucoma by assessing the correlation of the intereye difference in visual function as measured by standard automated perimetry (SAP) with the intereye difference in the afferent pupillary response.
Twenty-three patients with glaucoma underwent examination with a prototype, automated, binocular pupillometer. Correlation between the intereye difference in the afferent pupillary response and the intereye difference in mean deviation (MD) was explored.
Within 7 months of pupillography, all patients underwent SAP using the Humphrey Field Analyzer IIi, 24-2, Swedish Interactive Threshold Algorithm. The intereye differential pupillary response was 0.69±0.59 (log units, mean±SD). The intereye difference in MD was 5.67±5.29 dB (mean±SD). There was a strong correlation between the intereye difference in the afferent pupillary response and the intereye difference in MD (Spearman correlation coefficient, r = -0.77; P<0.001).
A new, binocular computerized pupillometer provides an automated method for the quantitative assessment of the afferent pupillary response. The intereye asymmetry in the pupil response correlates strongly with asymmetry in visual function, as measured by SAP, in patients with glaucoma.
通过评估标准自动视野计（SAP）测量的视功能的眼间差异与传入性瞳孔反应的眼间差异之间的相关性，来评估新型双目红外电脑瞳孔计在定量测量青光眼患者相对传入性瞳孔反应中的有效性。
对 23 例青光眼患者进行原型自动双目瞳孔计检查。探索传入性瞳孔反应的眼间差异与平均偏差（MD）的眼间差异之间的相关性。
在瞳孔图检查后 7 个月内，所有患者均使用 Humphrey Field Analyzer IIi，24-2，瑞典互动阈值算法进行 SAP。传入性瞳孔反应的眼间差异为 0.69±0.59（对数单位，均值±标准差）。MD 的眼间差异为 5.67±5.29 dB（均值±标准差）。传入性瞳孔反应的眼间差异与 MD 的眼间差异之间存在很强的相关性（Spearman 相关系数 r = -0.77；P<0.001）。
新型双目电脑瞳孔计提供了一种自动定量评估传入性瞳孔反应的方法。青光眼患者的瞳孔反应的眼间不对称与 SAP 测量的视功能的眼间不对称具有很强的相关性。
