Ferriani V P, Barbosa J E, de Carvalho I F
Department of Paediatrics, Faculty of Medicine of Riberão Preto, University of São Paulo, Brazil.
Acta Paediatr Scand. 1990 Mar;79(3):322-7. doi: 10.1111/j.1651-2227.1990.tb11464.x.
The haemolytic activity of complement was evaluated in the serum of healthy children from birth to 2 years of age using the kinetic method for the determination of the time needed to lyse 50% of target red cells (t 1/2). No sex-linked differences were observed in any of the age groups studied and the lowest lytic activity levels for both complement pathways were detected in neonates. The two pathways, however, showed different maturation patterns, i.e., lytic activity levels similar to those of adults were reached between the 1st and 3rd month of life (classical pathway) and around the 13th month (alternative pathway). In the age group of 7 to 24 months, the lytic activity of the classical pathway was higher than in adults. The present data permitted us to establish normal ranges of t 1/2 values for the classical and alternative pathways in serum of healthy neonates and children aged 1 to 24 months.
采用动力学方法测定使50%靶红细胞溶解所需的时间（t1/2），对出生至2岁健康儿童血清中的补体溶血活性进行了评估。在所研究的任何年龄组中均未观察到性别相关差异，并且在新生儿中检测到两条补体途径的最低溶血活性水平。然而，这两条途径表现出不同的成熟模式，即出生后第1至3个月（经典途径）和第13个月左右（替代途径）达到与成人相似的溶血活性水平。在7至24个月龄组中，经典途径的溶血活性高于成人。目前的数据使我们能够确定健康新生儿以及1至24个月龄儿童血清中经典途径和替代途径t1/2值的正常范围。
