Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Brain Res. 2013 May 20;1511:153-63. doi: 10.1016/j.brainres.2013.01.021. Epub 2013 Jan 18.
Optogenetics and novel designer receptors have revolutionized the way neuroscientists can interrogate neural circuits. These new tools are being rapidly applied to many facets of neuroscience including the study of Parkinson's disease circuitry and therapies. This review highlights how optogenetics and designer receptors can be applied in the study of Parkinsonian dysfunction to understand the mechanisms behind motor and non-motor symptoms. We discuss how these tools have recently advanced our understanding of basal ganglia function and outline how they can be applied in future to refine existing treatments and generate novel therapeutic strategies for Parkinson's disease. This article is part of a Special Issue entitled Optogenetics (7th BRES).
光遗传学和新型设计受体极大地改变了神经科学家研究神经回路的方式。这些新工具正在被迅速应用于神经科学的许多方面，包括帕金森病电路和疗法的研究。这篇综述强调了光遗传学和设计受体如何应用于帕金森病功能障碍的研究，以了解运动和非运动症状背后的机制。我们讨论了这些工具如何最近提高了我们对基底神经节功能的理解，并概述了它们如何在未来应用于改进现有的治疗方法并为帕金森病产生新的治疗策略。本文是主题为光遗传学（第 7 期 BRES）的特刊的一部分。
