Sekeryapan Berrak, Dılek Nursel, Oner Veysi, Turkyılmaz Kemal, Aslan Mehmet Gokhan
Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize, Turkey,
Int Ophthalmol. 2013 Oct;33(5):481-4. doi: 10.1007/s10792-013-9726-6. Epub 2013 Jan 23.
To evaluate the effect of oral isotretinoin therapy on retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness by spectral domain optical coherence tomography (OCT). This prospective study included newly diagnosed nodulocystic acne patients about to receive isotretinoin treatment. Macular average GCL thickness and peripapillary average, temporal, nasal, inferior, and superior quadrant RNFL thickness were measured by OCT before and after isotretinoin treatment. Pre- and post-treatment measurements were compared with paired t test. Fifty-six eyes of 28 patients were included. The mean duration of the treatment was 6.5 ± 1.3 months. The mean average GCL thickness was 90.04 ± 5.87 (80-96) μm at baseline and 90.75 ± 6.34 (81-96) μm after treatment. The mean average RNFL thickness was 93.25 ± 6.06 μm (84-107) before treatment and 93.05 ± 5.54 μm (82-106) after treatment. There were no statistically significant differences between pre- and post-treatment values (all p > 0.05). A 6-month course of systemic isotretinoin therapy seems to have no unfavorable effect on retinal ganglion cells; however, larger studies with longer follow-up periods are needed to be conclusive.
通过频域光学相干断层扫描（OCT）评估口服异维A酸治疗对视网膜神经纤维层（RNFL）和神经节细胞层（GCL）厚度的影响。这项前瞻性研究纳入了即将接受异维A酸治疗的新诊断结节囊肿性痤疮患者。在异维A酸治疗前后，通过OCT测量黄斑区平均GCL厚度以及视乳头周围平均、颞侧、鼻侧、下方和上方象限的RNFL厚度。治疗前后的测量值采用配对t检验进行比较。纳入了28例患者的56只眼。治疗的平均持续时间为6.5±1.3个月。基线时平均GCL厚度为90.04±5.87（80 - 96）μm，治疗后为90.75±6.34（81 - 96）μm。治疗前平均RNFL厚度为93.25±6.06μm（84 - 107），治疗后为93.05±5.54μm（82 - 106）。治疗前后的值之间无统计学显著差异（所有p>0.05）。为期6个月的系统性异维A酸治疗似乎对视网膜神经节细胞没有不利影响；然而，需要进行更大规模、随访期更长的研究才能得出结论。
