Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
Fitoterapia. 2012 Dec;83(8):1430-4. doi: 10.1016/j.fitote.2012.08.006.
Two new compounds, garciniacowol (1) and garciniacowone (2) along with 15 knowncompounds were isolated from the stem barks of Garcinia cowa. Their structures weredetermined by intensive spectroscopic methods. The structure of 1 was a symmetrical dimericdihydrobenzopyran derivative, whereas the framework of 2 was a triprenyl caged-xanthoneprecursor. The antibacterial activities against Escherichia coli TISTR 780, Salmonellatyphimurium TISTR 292, Staphylococcus aureus TISTR 1466, and methicillin-resistant S. aureus(MRSA) SK1 of the isolated compounds were also evaluated. Compounds 2 and 9 exhibitedgood antibacterial activity against MRSA SK1 with the same minimum inhibitory concentration(MIC) value of 2 μg/mL. Moreover, compound 2 also showed good antibacterial activityagainst S. aureus with an MIC value of 2 μg/mL.
从 Garcinia cowa 的茎皮中分离得到了两种新化合物，即 garciniacowol（1）和 garciniacowone（2），以及 15 种已知化合物。通过深入的光谱方法确定了它们的结构。化合物 1 的结构为对称二聚二氢苯并吡喃衍生物，而化合物 2 的骨架为三萜笼状黄烷酮前体。还评估了分离得到的化合物对大肠杆菌 TISTR 780、鼠伤寒沙门氏菌 TISTR 292、金黄色葡萄球菌 TISTR 1466 和耐甲氧西林金黄色葡萄球菌（MRSA）SK1 的抗菌活性。化合物 2 和 9 对 MRSA SK1 表现出良好的抗菌活性，最低抑菌浓度（MIC）值相同，均为 2 μg/mL。此外，化合物 2 对金黄色葡萄球菌也表现出良好的抗菌活性，MIC 值为 2 μg/mL。
