Wang Weiyi, Liao Yanyan, Huang Xiaomei, Tang Chao, Cai Peng
a Key Laboratory of Urban Environment and Health, Institute of Urban Environment , Chinese Academy of Sciences , Xiamen , P. R. China.
b University of Chinese Academy of Sciences , Beijing , P. R. China.
Nat Prod Res. 2018 Aug;32(15):1769-1774. doi: 10.1080/14786419.2017.1402315. Epub 2017 Nov 13.
A novel xanthone dimer derivative, garmoxanthone (1), together with 10 known compounds (2-11), were isolated from bark of Garcinia mangostana. Their structures were established through spectroscopic methods. Garmoxanthone exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of both 3.9 μg/mL) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 31.2 μg/mL). Garmoxanthone is a unique xanthone dimer with linkage of a fused 5/6 ring system and its absolute configuration was elucidated on the basis of experimental and calculated electronic circular dichroism. Garmoxanthone exhibited strong antibacterial activity which partially validated the ethnobotanical use of G. mangostana in the treatment of infections.
从山竹的树皮中分离出一种新型的氧杂蒽二聚体衍生物——藤黄氧杂蒽酮（1），以及10种已知化合物（2 - 11）。通过光谱方法确定了它们的结构。藤黄氧杂蒽酮对金黄色葡萄球菌ATCC 43300和金黄色葡萄球菌CGMCC 1.12409表现出强抑制活性（MIC值均为3.9μg/mL），对测试的弧菌菌株表现出中等活性（MIC值范围为15.6至31.2μg/mL）。藤黄氧杂蒽酮是一种具有稠合5/6环系统连接的独特氧杂蒽二聚体，其绝对构型是根据实验和计算的电子圆二色性阐明的。藤黄氧杂蒽酮表现出强抗菌活性，这部分验证了山竹在治疗感染方面的民族植物学用途。
