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本文引用的文献

1
Fluctuation: does blood pressure variability matter?波动：血压变异性重要吗？
Circulation. 2012 Jul 31;126(5):525-7. doi: 10.1161/CIRCULATIONAHA.112.124750. Epub 2012 Jul 3.
2
Reproducibility of visit-to-visit variability of blood pressure measured as part of routine clinical care.在常规临床护理中测量的血压日内变异性的可重复性。
J Hypertens. 2011 Dec;29(12):2332-8. doi: 10.1097/HJH.0b013e32834cf213.
3
The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994.在一般人群中，收缩压的访间变异性与全因死亡率之间的关系：来自 NHANES III 的研究结果，1988 年至 1994 年。
Hypertension. 2011 Feb;57(2):160-6. doi: 10.1161/HYPERTENSIONAHA.110.162255. Epub 2011 Jan 3.
4
Prognostic value of long-term blood pressure variability: the evidence is growing.长期血压变异性的预后价值：证据日益增多。
Hypertension. 2011 Feb;57(2):141-3. doi: 10.1161/HYPERTENSIONAHA.110.165852. Epub 2011 Jan 3.
5
Blood pressure variability: clarity for clinical practice.血压变异性：临床实践中的明晰要点
Hypertension. 2010 Aug;56(2):179-81. doi: 10.1161/HYPERTENSIONAHA.110.154708. Epub 2010 Jul 6.
6
Low medication adherence and hypertension control among adults with CKD: data from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.慢性肾脏病成人患者的药物治疗依从性低和高血压控制不佳：来自 REGARDS（中风地理和种族差异原因）研究的数据。
Am J Kidney Dis. 2010 Sep;56(3):447-57. doi: 10.1053/j.ajkd.2010.02.348. Epub 2010 May 14.
7
Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension.通常的血压假说的局限性以及变异性、不稳定性和间歇性高血压的重要性。
Lancet. 2010 Mar 13;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1.
8
Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis.降压药种类对血压个体间变异及卒中风险的影响：系统评价和荟萃分析。
Lancet. 2010 Mar 13;375(9718):906-15. doi: 10.1016/S0140-6736(10)60235-8.
9
Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension.血压变异性、收缩压最大值和偶发性高血压的预后意义。
Lancet. 2010 Mar 13;375(9718):895-905. doi: 10.1016/S0140-6736(10)60308-X.
10
Reproducibility of measures of visit-to-visit variability in blood pressure after transient ischaemic attack or minor stroke.短暂性脑缺血发作或轻度中风后血压逐次就诊变异性测量的可重复性。
Cerebrovasc Dis. 2009;28(4):331-40. doi: 10.1159/000229551. Epub 2009 Jul 24.

抗高血压药物治疗依从性与血压变异性的关系。

Association between antihypertensive medication adherence and visit-to-visit variability of blood pressure.

机构信息

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

出版信息

J Clin Hypertens (Greenwich). 2013 Feb;15(2):112-7. doi: 10.1111/jch.12037. Epub 2012 Nov 28.

DOI:10.1111/jch.12037
PMID:23339729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3659162/
Abstract

It has been hypothesized that high visit-to-visit variability (VVV) of systolic blood pressure (SBP) may be the result of poor antihypertensive medication adherence. The authors studied this association using data from 1391 individuals taking antihypertensive medication selected from a large managed care organization. The 8-item Morisky Medication Adherence Scale, administered during 3 annual surveys, captured self-report adherence, with scores<6, 6 to <8, and 8 representing low, medium. and high adherence, respectively. The mean (standard deviation [SD]) for SD of SBP across study visits was 12.9 (4.4), 13.5 (4.8), and 14.1 (4.5) mm Hg in participants with high, medium, and low self-reported adherence, respectively. After multivariable adjustment and compared with those with high self-report adherence, SD of SBP was 0.60 (95% confidence interval, 0.13-1.07) and 1.08 (95% confidence interval, 0.29-1.87) mm Hg higher among participants with medium and low self-report adherence, respectively. Results were consistent when pharmacy fill was used to define adherence. These data suggest that low antihypertensive medication adherence explains only a small proportion of VVV of SBP.

摘要

有人假设，收缩压（SBP）的就诊间变异性（VVV）高可能是降压药物治疗依从性差的结果。作者使用从大型管理式医疗组织中选择的 1391 名服用降压药物的个体的数据研究了这种关联。在 3 项年度调查中使用了 8 项 Morisky 药物依从性量表来评估自我报告的依从性，得分<6、6 至<8 和 8 分别代表低、中、高依从性。高、中、低自我报告依从性的参与者的 SBP 就诊间标准差（SD）分别为 12.9（4.4）、13.5（4.8）和 14.1（4.5）mmHg。经过多变量调整后，与高自我报告依从性的参与者相比，中、低自我报告依从性的参与者的 SBP 就诊间 SD 分别高 0.60（95%置信区间，0.13-1.07）和 1.08（95%置信区间，0.29-1.87）mmHg。当使用药房配药来定义依从性时，结果是一致的。这些数据表明，降压药物治疗的低依从性仅能解释 SBP VVV 的一小部分。