Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Dermatitis. 2013 Jan-Feb;24(1):29-32. doi: 10.1097/DER.0b013e31827edc8b.
Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction that occurs when a previously photosensitized exogenous agent comes into contact with UV radiation. Currently, there are no studies profiling photoallergic reactions in Canada. Because the photoallergen profile changes over time, it is necessary to continually update our knowledge to ensure proper recognition of allergens and appropriate treatment of patients.
This study aimed to profile photoallergic reactions in Canada.
A retrospective chart review of all patients who underwent photopatch testing at Toronto Western Hospital between January 2001 and December 2010 was completed. Photoallergic, allergic, and irritant reactions were recorded for 26 common allergens.
Ninety-nine patients (61.9%) had at least 1 positive reaction to the test allergens. Fifty-four patients (33.8%) had at least 1 photoallergic reaction. All 26 allergens produced at least 1 allergic or photoallergic reaction. The most common relevant photoallergens were benzophenone-3, octyl dimethyl para-aminobenzoic acid (PABA) in 5% alcohol, and butylmethoxy-dibenzoylmethane.
This study is the first to profile photoallergic contact reactions in Canada. It is clear that the culprit photoallergen in PACD can often be identified in a properly selected population. Future surveillance is necessary to continue to characterize PACD trends in Canada and to help better treat and screen this patient population.
光变应性接触性皮炎（PACD）是一种超敏反应，当先前光敏的外源性物质接触到紫外线辐射时就会发生。目前，加拿大还没有研究描述光变应性反应。由于光变应原的特征随时间而变化，因此有必要不断更新我们的知识，以确保正确识别变应原并对患者进行适当治疗。
本研究旨在描述加拿大的光变应性反应。
对 2001 年 1 月至 2010 年 12 月期间在多伦多西部医院接受光斑贴试验的所有患者进行了回顾性病历审查。记录了 26 种常见过敏原的光变应性、变应性和刺激性反应。
99 名患者（61.9%）对试验变应原至少有 1 个阳性反应。54 名患者（33.8%）至少有 1 次光变应性反应。所有 26 种过敏原均至少产生 1 次变应性或光变应性反应。最常见的相关光变应原是二苯甲酮-3、5%酒精中的辛基二甲基对氨基苯甲酸（PABA）和丁基甲氧基二苯甲酰基甲烷。
本研究首次描述了加拿大的光变应性接触反应。显然，在适当选择的人群中，通常可以确定 PACD 的罪魁祸首光变应原。未来的监测是必要的，以继续描述加拿大 PACD 的趋势，并帮助更好地治疗和筛选这一患者群体。
