Department of Dermatology, Ninewells Hospital, Dundee DD1 9SY, UK.
Br J Dermatol. 2012 May;166(5):1002-9. doi: 10.1111/j.1365-2133.2012.10857.x.
The two most common agent groups currently responsible for photoallergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce.
To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe.
A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries.
A total of 346 PACD reactions in 200 (19·4%) subjects occurred. PACD was most commonly caused by the topical NSAIDs, ketoprofen (128 subjects) and etofenamate (59 subjects). Of the organic UV absorbers, octocrylene, benzophenone-3 and butyl methoxydibenzoylmethane most frequently elicited PACD. The 'newer' organic sunscreen absorbers rarely led to PACD. There appeared to be an association between the agents ketoprofen, octocrylene and benzophenone-3, with several subjects developing PACD to two or all three agents concomitantly. Allergic contact dermatitis (ACD) was less commonly observed than PACD, comprising 55 reactions in 47 (5%) subjects. Irritant reactions and photoaugmentation and photoinhibition of ACD occurred infrequently.
The European multicentre photopatch test study has provided current information on the relative frequency of PACD to common photoallergens. Such data will be of value when deciding on which agents to include in a future European 'baseline' photopatch test series.
目前引起光变应性接触性皮炎（PACD）的最常见的两类物质是防晒霜中的有机紫外线（UV）吸收剂和局部非甾体抗炎药（NSAIDs）。然而，有关这些物质光变应原性的信息却很少。
获得目前有关欧洲常用的 19 种有机 UV 吸收剂和 5 种局部 NSAIDs 引起 PACD 的频率的信息，包括新型制剂。
对来自 12 个欧洲国家 30 个中心的 1031 例疑似 PACD 患者进行了一项前瞻性、多中心光斑贴试验研究。
在 200 例（19.4%）受试者中，共发生了 346 例 PACD 反应。PACD 最常见的原因是局部 NSAIDs，如酮洛芬（128 例）和依托芬那酯（59 例）。在有机 UV 吸收剂中，奥克立林、二苯甲酮-3 和丁基甲氧基二苯甲酰基甲烷最常引起 PACD。新型有机防晒霜吸收剂很少引起 PACD。酮洛芬、奥克立林和二苯甲酮-3 之间似乎存在关联，一些患者同时对两种或三种物质产生 PACD。与 PACD 相比，过敏接触性皮炎（ACD）的发生率较低，包括 47 例（5%）受试者的 55 例反应。ACD 常表现为刺激性反应，且少见光增强和光抑制。
这项欧洲多中心光斑贴试验研究提供了有关常见光变应原引起 PACD 的相对频率的最新信息。在决定未来欧洲“基线”光斑贴试验系列中包含哪些物质时，此类数据将具有重要价值。
