Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chem Commun (Camb). 2013 Feb 25;49(16):1636-8. doi: 10.1039/c3cc39012h.
An enantioselective direct α-alkylation of 2-oxindoles with Michler's hydrol via an S(N)1-type pathway in the non-covalent activation mode using the bis-cinchona alkaloid and Brønsted acid as a co-catalyst was developed and good to high yields and enantioselectivities were obtained.
通过非共价活化模式下双金鸡纳碱和布朗斯特酸作为共催化剂，米歇儿试剂通过 S(N)1 型反应路径实现了对 2-氧吲哚的对映选择性直接α-烷基化反应，获得了良好到优秀的产率和对映选择性。
