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硬膜外电刺激试验不能预测分娩时硬膜外镇痛中局部麻醉药的扩散或消耗。

The epidural electric stimulation test does not predict local anesthetic spread or consumption in labour epidural analgesia.

机构信息

Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

出版信息

Can J Anaesth. 2013 Apr;60(4):393-8. doi: 10.1007/s12630-013-9887-9. Epub 2013 Jan 24.

Abstract

PURPOSE

The epidural electrical stimulation test (EEST) is a highly specific and sensitive test for confirming placement of the epidural catheter in the epidural space. The purpose of this study was to investigate if the EEST could predict the spread and consumption of local anesthetic solutions during labour epidural analgesia.

METHODS

This observational study was conducted in labouring parturients requesting epidural analgesia. The EEST was performed after the epidural catheter placement (T0) and repeated five minutes after a test dose with 2% lidocaine 3 mL (T1). The minimum current required to elicit the motor response at each time point was recorded. A loading dose of 0.125% bupivacaine 10 mL and fentanyl 50 μg was administered and followed by patient-controlled epidural analgesia with 0.0625% bupivacaine and fentanyl 2 μg·mL(-1) (baseline infusion 10 mL·hr(-1), bolus dose 5 mL, lockout interval ten minutes, maximum dose 20 mL·hr(-1)). The primary outcome was the correlation between the current required to elicit motor responses at T0 and T1 and the consumption of bupivacaine in the first two hours of epidural administration. The secondary outcomes included the muscle contraction patterns determined by the EEST and the incidence of failed, inadequate, or asymmetric blocks.

RESULTS

The study was conducted in 102 parturients. The mean electric current required to elicit muscle response was 4.43 mA (range 1-10 mA) at T0, 5.97 mA (range 1-14 mA) at T1, and the mean Δ (T1-T0) current was 1.54 mA (range 0-8 mA). There was no correlation between either the mean baseline current required or the Δ (T1-T0) current and the total bupivacaine consumption at two hours. The incidence of inadequate blocks at two hours was 18%; however, none of the catheters required replacement. Unilateral left (34%) or right (31%) leg contraction was the most frequent pattern elicited by the EEST.

CONCLUSIONS

The EEST shows a wide range of electrical current requirements and elicits a variety of muscle twitch patterns on the lower limbs. Although it confirms the epidural placement of the catheter, the EEST cannot be used to predict the spread or consumption of the local anesthetic solution during labour epidural analgesia.

摘要

目的

硬膜外电刺激试验(EEST)是一种高度特异和敏感的试验,可用于确认硬膜外导管在硬膜外腔中的位置。本研究的目的是探讨 EEST 是否可以预测分娩时硬膜外镇痛中局部麻醉溶液的扩散和消耗。

方法

本观察性研究在请求硬膜外镇痛的分娩产妇中进行。在硬膜外导管放置后(T0)进行 EEST,并在 2%利多卡因 3 mL 测试剂量后 5 分钟(T1)重复进行。记录每个时间点引起运动反应所需的最小电流。给予 0.125%布比卡因 10 mL 和芬太尼 50 μg 的负荷剂量,然后进行患者自控硬膜外镇痛,使用 0.0625%布比卡因和芬太尼 2 μg·mL(-1)(基础输注 10 mL·hr(-1),推注剂量 5 mL,锁定间隔 10 分钟,最大剂量 20 mL·hr(-1))。主要结局是 T0 和 T1 时引起运动反应所需的电流与硬膜外给药后 2 小时内布比卡因消耗之间的相关性。次要结局包括 EEST 确定的肌肉收缩模式和失败、不足或不对称阻滞的发生率。

结果

该研究纳入了 102 名产妇。T0 时引起肌肉反应所需的平均电流为 4.43 mA(范围 1-10 mA),T1 时为 5.97 mA(范围 1-14 mA),T1-T0 时的平均电流差为 1.54 mA(范围 0-8 mA)。基线电流的平均值或 T1-T0 时的电流差值与 2 小时内的布比卡因总消耗量均无相关性。2 小时时不足阻滞的发生率为 18%;然而,没有一个导管需要更换。EEST 最常引起单侧左侧(34%)或右侧(31%)腿部收缩。

结论

EEST 显示出广泛的电流需求,并在下肢引起各种肌肉抽搐模式。尽管它确认了导管在硬膜外的位置,但 EEST 不能用于预测分娩时硬膜外镇痛中局部麻醉溶液的扩散或消耗。

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