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用于小儿惊厥性癫痫发作的口腔咪达唑仑：疗效、安全性及患者可接受性。

Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability.

作者信息

Anderson Mark

机构信息

Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.

出版信息

Patient Prefer Adherence. 2013;7:27-34. doi: 10.2147/PPA.S39233. Epub 2013 Jan 10.

DOI:10.2147/PPA.S39233
PMID:23341735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3546805/
Abstract

Prolonged seizures and status epilepticus are a common acute neurological presentation in pediatric practice. As a result, there is a need for effective and safe medications that can be delivered to convulsing children to effect rapid seizure termination both in hospital and community settings. The challenges of achieving intravenous access, particularly in young children, mandate alternative routes of administration for these drugs. Over the last ten years, midazolam delivered via the buccal mucosa has been demonstrated to be efficacious, safe, and acceptable to children and their caregivers, and a formulation has recently been licensed for use in Europe. The aim of this article is to review the clinical pharmacology with respect to these issues.

摘要

长时间癫痫发作和癫痫持续状态是儿科临床常见的急性神经科症状。因此，需要有有效且安全的药物，以便在医院和社区环境中给惊厥儿童使用，从而迅速终止癫痫发作。建立静脉通路存在困难，尤其是在幼儿中，这就要求这些药物采用其他给药途径。在过去十年中，经颊黏膜给予咪达唑仑已被证明是有效、安全的，并且儿童及其护理人员都能接受，最近有一种制剂已在欧洲获得使用许可。本文旨在就这些问题综述其临床药理学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae3/3546805/add098a92986/ppa-7-027f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae3/3546805/add098a92986/ppa-7-027f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae3/3546805/add098a92986/ppa-7-027f1.jpg

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2
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Adv Drug Deliv Rev. 2012 Jul;64(10):911-8. doi: 10.1016/j.addr.2012.01.017. Epub 2012 Feb 3.
3
Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers.健康成年志愿者中口腔和鼻内劳拉西泮的药代动力学。
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Pharmaceutics. 2021 Sep 15;13(9):1480. doi: 10.3390/pharmaceutics13091480.
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A Short Review on the Intranasal Delivery of Diazepam for Treating Acute Repetitive Seizures.关于鼻内给予地西泮治疗急性重复性癫痫发作的简短综述。
Pharmaceutics. 2020 Nov 30;12(12):1167. doi: 10.3390/pharmaceutics12121167.
5
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Neuropsychiatr Dis Treat. 2016 Feb 24;12:467-85. doi: 10.2147/NDT.S80586. eCollection 2016.
6
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9
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