Banna P, Stivala F, Murabito R, Cordopatri F, Saggio A, Mosca F, Cinà C
Chir Ital. 1979 Dec;31(6):1297-1313.
It is by now an established fact that the status of the immune system stands in some relationship with the onset and evolution of malignancy. To clarify this relationship the authors investigated the immune system of patients with pulmonary carcinoma, with special regard to the functions of the T and B lymphocyte lines. After suitable explanation of their experimental protocol, which involved immunological monitoring and the study of relationships between immunological changes and the extent and histological type of malignancy, and also the effects of any treatments being administered, the authors describe the results obtained in 18 preoperative patients. The study revealed an overall diminution of cell-mediated immune activity: less strongly positive DNCB skin tests, reduced capacity for making E rosettes, reduced blast transformation with PHA. With B lymphocytes the EA rosette test was often depressed, whereas antibody titers were normal or even above normal, and the pokeweed blast test was invariable above normal values. These preliminary results show that at the time of diagnosing malignancy, the greater aggressiveness characteristic of the less differentiated cellular types, or of stages of diffuse malignancy, is associated with overpowering of cell defenses and (within certain limits) enhancement of the humoral response.
目前，免疫系统的状态与恶性肿瘤的发生和发展存在某种关联，这已是既定事实。为阐明这种关系，作者对肺癌患者的免疫系统进行了研究，特别关注T和B淋巴细胞系的功能。在对其实验方案进行适当解释后（该方案涉及免疫监测以及免疫变化与恶性肿瘤的范围和组织学类型之间关系的研究，还包括所施用的任何治疗的效果），作者描述了18例术前患者的研究结果。该研究显示细胞介导的免疫活性总体下降：二硝基氯苯皮肤试验阳性反应减弱、形成E花环的能力降低、对PHA的母细胞转化反应降低。对于B淋巴细胞，EA花环试验常受抑制，而抗体滴度正常甚至高于正常，且商陆母细胞试验始终高于正常值。这些初步结果表明，在诊断恶性肿瘤时，低分化细胞类型或弥漫性恶性肿瘤阶段更具侵袭性的特征与细胞防御功能的压倒性以及（在一定范围内）体液反应的增强有关。
