UOC Genetics and Immunology Paediatrics, University of Messina, Messina, Italy.
Int Arch Allergy Immunol. 2013;161(2):116-21. doi: 10.1159/000345246. Epub 2013 Jan 22.
Allergic rhinitis (AR) is characterized by an inflammatory reaction. High-mobility group box-1 protein (HMGB1) has many characteristics similar to classic proinflammatory cytokines. No study has yet investigated its role in AR. The aim of this study was to measure HMGB1 levels in the fluid recovered from nasal lavage in children with untreated AR and in control subjects.
The study was conducted on 104 AR subjects (48 males and 56 females, median age 10.3 ± 3.4 years) and 97 healthy children (42 males and 55 females) who were age-matched (median age 9.8 ± 4.1 years). Total serum immunoglobulin E, peripheral eosinophils and nasal symptoms assessed by visual analog scale (VAS) were considered. HMGB1 was measured using an ELISA assay.
HMGB1 levels in nasal lavage fluid were higher in AR children than in the control group (96.9 ± 19.3 vs. 9.27 ± 4.01 ng/ml; p < 0.001). There was a very strong relationship between HMGB1 levels and VAS values in AR children (r = 0.919). Considering the symptom severity assessed by VAS, there was a relationship between HMGB1 and VAS in all AR subgroups: more evident in the severe subgroup (r = 0.727).
Nasal HMGB1 has significantly increased in children with AR and is significantly related to symptom severity.
过敏性鼻炎（AR）的特征是炎症反应。高迁移率族蛋白 B1（HMGB1）具有许多与经典促炎细胞因子相似的特征。目前还没有研究探讨其在 AR 中的作用。本研究旨在测量未经治疗的 AR 患儿和对照组患儿鼻灌洗液中 HMGB1 的水平。
该研究共纳入 104 例 AR 患儿（48 名男性和 56 名女性，中位年龄 10.3±3.4 岁）和 97 例健康儿童（42 名男性和 55 名女性），两组年龄匹配（中位年龄 9.8±4.1 岁）。考虑了总血清免疫球蛋白 E、外周嗜酸性粒细胞和视觉模拟量表（VAS）评估的鼻部症状。采用 ELISA 法测定 HMGB1。
AR 患儿鼻灌洗液中 HMGB1 水平高于对照组（96.9±19.3 与 9.27±4.01ng/ml；p<0.001）。AR 患儿 HMGB1 水平与 VAS 值之间存在很强的相关性（r=0.919）。考虑到 VAS 评估的症状严重程度，AR 患儿的 HMGB1 与 VAS 之间存在相关性：在严重亚组中更为明显（r=0.727）。
AR 患儿的鼻腔 HMGB1 明显增加，与症状严重程度显著相关。
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