Yousefi-Mashouf R, Moshtaghi Aa
Dept. of Medical Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran.
J Res Health Sci. 2007 Jul 28;7(1):49-56.
To determine the prevalence of typhoidal and non-typhoidal Salmonella species in Hamadan City, west of Iarn and detection of antibiotic susceptibility patterns of isolates.
In a cross-sectional descriptive study, 296 Salmonella species including 192 strains of typhoidal Salmonella and 104 strains of non- typhoidal Salmonella were examined for serotyping and determining of antibiotic susceptibility. The strains were collected from patients referred to cilinical centers in Hamadan during 2001 to 2004. They were serotyped and then tested for their antibiotic susceptibility patterns, using Stokes disc diffusion method for 8 antibiotics.
Among 296 samples, 64.8% were typhoidal and 35.2% were non-typhoidal Salmonella species. Typhoidal Salmonella species were as follows: S. typhi 45.6%, S. paratyphi B 8.1%, S. paratyphi C 7.1% and S. paratyphi a 4.7%. Non-typhoidal Salmonella species were as follows: S.typhimurium 21.2%, S.enteritidis 4.4%, S. species 2.1%, S. cholerasuis 1.7%, S. arizona 1.3%, S. agona 1.1%, S. thompson 0.7%, S.muenchen, S.lexington and S. hirschfeldii 0.35%. A proportion of strains ( > 60%) were resistance to cefotaxime and ampicillin. Resistance to ciprofloxacin and amikacin was very low ( < 15%). S.typhimurim (100%), S. typhi (95.7%) S. paratyphi B (89.2%) and S. enteitidis (60%) showed multi-drug resistance.
S. typhi and S. typhimurium were the most predominant serotypes in this area. Most of the Salmonella species isolated from patients were resistant to beta-lactam antibiotics and co-trimoxazole, whereas, most of them were sensitive to ciprofloxacin, gentamicin and amikacin. As the prevalence of multidrug-resistant serovar Typhi increases, newer, more expensive, and less readily available antimicrobial agents will be required for the treatment of typhoid.
确定伊朗西部哈马丹市伤寒和非伤寒沙门氏菌的流行情况，并检测分离株的抗生素敏感性模式。
在一项横断面描述性研究中，对296株沙门氏菌进行了血清分型和抗生素敏感性测定，其中包括192株伤寒沙门氏菌和104株非伤寒沙门氏菌。这些菌株于2001年至2004年期间从转诊至哈马丹临床中心的患者中收集。对其进行血清分型，然后使用斯托克斯纸片扩散法对8种抗生素检测其抗生素敏感性模式。
在296个样本中，64.8%为伤寒沙门氏菌，35.2%为非伤寒沙门氏菌。伤寒沙门氏菌种类如下：伤寒杆菌45.6%，副伤寒杆菌B 8.1%，副伤寒杆菌C 7.1%，副伤寒杆菌A 4.7%。非伤寒沙门氏菌种类如下：鼠伤寒杆菌21.2%，肠炎沙门氏菌4.4%，其他沙门氏菌2.1%，猪霍乱沙门氏菌1.7%，亚利桑那沙门氏菌1.3%，阿哥纳沙门氏菌1.1%，汤普森沙门氏菌0.7%，慕尼黑沙门氏菌、列克星敦沙门氏菌和赫希菲尔德沙门氏菌0.35%。一部分菌株（>60%）对头孢噻肟和氨苄西林耐药。对环丙沙星和阿米卡星的耐药率很低（<15%）。鼠伤寒杆菌（100%）、伤寒杆菌（95.7%）、副伤寒杆菌B（89.2%）和肠炎沙门氏菌（60%）表现出多重耐药。
伤寒杆菌和鼠伤寒杆菌是该地区最主要的血清型。从患者中分离出的大多数沙门氏菌对β-内酰胺类抗生素和复方新诺明耐药，而大多数对环丙沙星、庆大霉素和阿米卡星敏感。随着多重耐药伤寒血清型流行率的增加，治疗伤寒将需要更新、更昂贵且更难获得的抗菌药物。
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