肽介导的反义寡核苷酸和小干扰RNA的细胞及体内递送 - Suppr

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超能文献

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA.

作者信息

Järver Peter, Coursindel Thibault, Andaloussi Samir El, Godfrey Caroline, Wood Matthew Ja, Gait Michael J

机构信息

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

出版信息

Mol Ther Nucleic Acids. 2012 Jun 12;1(6):e27. doi: 10.1038/mtna.2012.18.

DOI:10.1038/mtna.2012.18

PMID:23344079

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3390225/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75cf/3390225/f6c2f802f9b7/mtna201218f1.jpg

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本文引用的文献

Allele-selective inhibition of trinucleotide repeat genes.三核苷酸重复基因的等位基因选择性抑制。

Drug Discov Today. 2012 May;17(9-10):443-50. doi: 10.1016/j.drudis.2012.01.006. Epub 2012 Jan 18.

RNA therapeutics: beyond RNA interference and antisense oligonucleotides.RNA 疗法：超越 RNA 干扰和反义寡核苷酸。

Nat Rev Drug Discov. 2012 Jan 20;11(2):125-40. doi: 10.1038/nrd3625.

Exploiting cell surface thiols to enhance cellular uptake.利用细胞表面巯基增强细胞摄取。

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Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery.细胞穿透肽作为核酸传递的多功能载体。

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Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides.利用穿透肽实现核酸药物的高效细胞内递送。

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Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise.用于 siRNA 递送的聚合物：受病毒启发，具有靶向性、动态性和精确性。

Acc Chem Res. 2012 Jul 17;45(7):1005-13. doi: 10.1021/ar2002232. Epub 2011 Dec 22.

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Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo.利用靶标保护寡核苷酸分析特定 miRNA-mRNA 对在体内的生理作用。

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