从乌桕种子中分离得到的两种脑苷脂及其神经保护作用。

Two cerebrosides isolated from the seeds of Sterculia lychnophora and their neuroprotective effect.

机构信息

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.

出版信息

Molecules. 2013 Jan 17;18(1):1181-7. doi: 10.3390/molecules18011181.

DOI:10.3390/molecules18011181

PMID:23344207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6270611/

Abstract

Two cerebrosides named 1-O-b-D-glucopyranosyl-(2S,3R,4E,8Z)-2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol (1) and soya-cerebroside I (2) were isolated from the seeds of Sterculia lychnophora for the first time. Their structures were completely characterized by spectroscopic methods including IR, MS and NMR. Compound 1 exhibited moderate neuroprotective effect against SH-SY5Y cell damage induced by hydrogen peroxide.

摘要

首次从乌桕种子中分离得到两种神经酰胺，分别命名为 1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8Z)-2-[(2-羟基十八烷酰基)氨基]-4,8-十八碳二烯-1,3-二醇（1）和大豆神经酰胺 I（2）。通过红外光谱（IR）、质谱（MS）和核磁共振（NMR）等光谱方法对它们的结构进行了全面表征。化合物 1 对过氧化氢诱导的 SH-SY5Y 细胞损伤具有中等的神经保护作用。