Institute of Photonic Technology (IPHT), Albert Einstein Strasse 9, 07745 Jena, Germany.
Lab Chip. 2013 Mar 21;13(6):1109-13. doi: 10.1039/c2lc41169e.
An all-fibre based Raman-on-chip setup is introduced which enables analysis of solutions and trapped particles without microscopes or objectives. Beside the novel quartz microfluidic chip, innovative multi-core single-mode fibres with integrated fibre Bragg gratings are used for detection. The limit of quantitation is 7.5 mM for urea and 2.5 mM for nicotine with linear Raman spectroscopy. This is an improvement of more than two orders of magnitude compared with previous fibre-based microfluidic Raman detection schemes. Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads.
本文介绍了一种全光纤片上拉曼系统，该系统无需显微镜或物镜即可对溶液和捕获颗粒进行分析。除了新型的石英微流控芯片，还使用了具有集成光纤布拉格光栅的创新型多芯单模光纤进行检测。使用线性拉曼光谱法，尿素的定量限为 7.5mM，尼古丁的定量限为 2.5mM。与以前的光纤微流控拉曼检测方案相比，这提高了两个数量级以上。此外，我们的装置与光阱结合，用于收集球形聚合物珠的片上拉曼光谱。
