钙拮抗剂领域的构效关系研究。带有2,3-内酯环的呫吨酮1,4-二氢吡啶类化合物。
Structure-activity relationship studies in the field of calcium antagonists. Xanthone 1,4-dihydropyridines bearing a 2,3-lactone ring.
作者信息
Rampa A, Budriesi R, Bisi A, Fabbri G, Barili P L, Chiarini A, Valenti P
机构信息
Department of Pharmaceutical Sciences, University of Bologna, Italy.
出版信息
Arzneimittelforschung. 1995 Sep;45(9):957-62.
PMID:7488312
Abstract
A series of xanthone 1,4-dihydropyridine derivatives bearing a 2,3-lactone ring and a 2-acetoxymethyl group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The introduction of a 2,3-lactone ring improved the negative inotropic activity and selectivity.
摘要
制备了一系列带有2,3-内酯环和2-乙酰氧基甲基的呫吨-1,4-二氢吡啶衍生物。对这些化合物的变力性、变时性和钙拮抗特性进行了评估。2,3-内酯环的引入提高了负性变力活性和选择性。
Zotero 插件