Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Nat Rev Cancer. 2013 Feb;13(2):136-43. doi: 10.1038/nrc3446.
The role of p63 in cancer has been an area of intense debate and controversy. Is TP63 (which encodes p63) a tumour suppressor gene or an oncogene? This debate is partly due to the complexity of the gene. There are several p63 isoforms - some with tumour suppressive functions and others with oncogenic functions. In this Opinion article, we focus on the recent advances in understanding p63 biology and its roles in cancer. In this regard, we discuss the role of p63 in multiple stem cell compartments, ageing, in the response to DNA damage and in DNA repair. Finally, we highlight the importance of understanding the interactions between all three p53 family members and the potential impact of this knowledge on cancer therapy and regenerative medicine.
p63 在癌症中的作用一直是激烈争论和争议的领域。TP63（编码 p63）是抑癌基因还是癌基因？这种争论部分归因于基因的复杂性。有几种 p63 异构体 - 有些具有肿瘤抑制功能，有些具有致癌功能。在这篇观点文章中，我们专注于理解 p63 生物学及其在癌症中的作用的最新进展。在这方面，我们讨论了 p63 在多个干细胞隔室、衰老、对 DNA 损伤的反应以及 DNA 修复中的作用。最后，我们强调了理解 p53 家族所有三个成员之间相互作用的重要性及其对癌症治疗和再生医学的潜在影响。
