Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic.
Cell Mol Biol Lett. 2011 Jun;16(2):296-327. doi: 10.2478/s11658-011-0009-9. Epub 2011 Mar 20.
The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.
转录因子 p63 在肿瘤发生、表皮分化和干细胞自我更新中具有重要功能。TP63 基因编码多种蛋白异构体，它们在这些过程中具有不同甚至拮抗的作用。p63 异构体的平衡，以及其他 p53 家族成员 p73 和 p53 的存在或缺失，具有显著的生物学影响。越来越多的证据表明，p53 家族成员之间的相互作用，无论是合作还是拮抗，都参与了各种细胞过程。这篇综述总结了目前对 p63 在肿瘤发生、转移、细胞迁移和衰老中的作用的理解。特别是，最近的数据表明其在成体干细胞和癌症干细胞调控以及癌细胞对治疗的反应中具有重要作用。
