State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China.
Environ Toxicol Chem. 2013 Apr;32(4):757-63. doi: 10.1002/etc.2124. Epub 2013 Feb 21.
The tissue-specific accumulation and species-specific metabolism of polybrominated diphenyl ethers (PBDEs) in two predator fish species (redtail catfish and oscar fish) feeding on the same prey (tiger barb) that was exposed to technical pentabrominated diphenyl ether (DE-71) in the laboratory were investigated. The trends in the wet-weight tissue concentration of PBDEs in two predatory fish species suggested that the tissue distribution of PBDEs occurs through a series of events involving passive diffusion to the lipid compartment. A comparison of the fugacities of PBDEs in various tissues and in the serum revealed that the liver, gill, and perivisceral adipose tissue readily achieved equilibrium with the serum, but the muscle, kidney, and intestine exhibited the potential to accumulate PBDEs. The lower fugacities of PBDEs in the intestine may have significance in the transportation of PBDEs from prey to predatory fish. No tissue-specific differences in PBDE congener profiles were found, while interspecies differences in PBDE profiles were evident. The difference in profiles between two species could be attributed to species-specific debromination of PBDE. No metabolic debromination of PBDE was observed in redtail catfish, but extensive debromination of PBDEs occurred in oscar fish. Several hydroxylated PBDEs (OH-PBDEs) were detected in serum samples from the two fish species, but no methoxylated PBDEs were found. The similarities in the OH-PBDE congener profile and the ratio of OH-PBDEs to total PBDEs between the two fish species indicated that the hydroxylation of PBDEs might not be species-specific.
研究了两种掠食性鱼类（红尾鲶鱼和奥斯卡鱼）在实验室中摄食暴露于五溴二苯醚（DE-71）的同种猎物（虎皮鱼）时，多溴二苯醚（PBDEs）在组织中的特异性积累和种间特异性代谢。两种掠食性鱼类湿重组织中 PBDE 浓度的变化趋势表明，PBDEs 的组织分布是通过一系列涉及被动扩散到脂质隔室的事件发生的。比较各种组织和血清中 PBDE 的逸度表明，肝脏、鳃和内脏脂肪组织很容易与血清达到平衡，但肌肉、肾脏和肠有积累 PBDE 的潜力。肠中 PBDE 的逸度较低，这可能对 PBDE 从猎物向掠食性鱼类的运输具有重要意义。未发现 PBDE 同系物谱在组织中有特异性差异，而种间差异明显。两种物种之间的 PBDE 谱差异可能归因于 PBDE 的种特异性脱溴作用。在红尾鲶鱼中未观察到 PBDE 的代谢脱溴作用，但在奥斯卡鱼中发生了广泛的 PBDE 脱溴作用。在两种鱼类的血清样本中检测到几种羟基化 PBDE（OH-PBDEs），但未发现甲氧基化 PBDEs。两种鱼类之间 OH-PBDE 同系物谱和 OH-PBDE 与总 PBDE 比值的相似性表明，PBDE 的羟基化可能不是种特异性的。
