Kaya Ahmet, Kurt Mustafa, Tanboga Ibrahim Halil, Işık Turgay, Günaydın Zeki Yüksel, Kaya Yasemin, Topçu Selim, Sevimli Serdar
Department of Cardiology, Ordu University Medical School, Ordu, Turkey
Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
Clin Appl Thromb Hemost. 2014 Jul;20(5):473-7. doi: 10.1177/1076029612473517. Epub 2013 Jan 23.
We examined the association between neutrophil to lymphocyte ratio (NLR) and the complexity of coronary artery disease assessed by SYNTAX score (SS).
The study population included patients with chest pain who had undergone coronary angiography for stable angina pectoris. Patients were classified depending on whether the SS was 0 or SS > 0.
Left ventricular ejection fraction, estimated glomerular filtration rate, and NLR were found to be the independent predictors of high SS in multivariate analysis. The area under the receiver-operating curve of NLR was 0.72 (0.65-0.80, P < .001) for predicting high SS. The optimal cutoff value of NLR to predict high SS was 2.7 (sensitivity of 72% and a specificity of 61%). There was a significant correlation between NLR ratio and continuous SS (r = .552, P < .001).
The NLR is a readily measurable systemic inflammatory marker and is associated with both the presence and the complexity of coronary artery disease.
我们研究了中性粒细胞与淋巴细胞比值（NLR）与通过SYNTAX评分（SS）评估的冠状动脉疾病复杂性之间的关联。
研究人群包括因稳定型心绞痛接受冠状动脉造影的胸痛患者。根据SS是否为0或SS>0对患者进行分类。
在多变量分析中，左心室射血分数、估计肾小球滤过率和NLR被发现是高SS的独立预测因素。NLR的受试者工作特征曲线下面积为0.72（0.65-0.80，P<.001），用于预测高SS。预测高SS的NLR最佳截断值为2.7（敏感性为72%，特异性为61%）。NLR比值与连续SS之间存在显著相关性（r=.552，P<.001）。
NLR是一种易于测量的全身炎症标志物，与冠状动脉疾病的存在和复杂性均相关。
