Zhang G-Y, Chen M, Yu Z-M, Wang X-D, Wang Z-Q
Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Genet Mol Res. 2014 Nov 11;13(4):9382-9. doi: 10.4238/2014.November.11.4.
This study aimed to investigate the relation between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery stenosis. A total of 219 patients were included in the study, comprising 51 coronary artery atherosclerosis (CAC) patients, 92 stable angina pectoris (SAP) patients, and 76 acute coronary syndrome (ACS) patients. Based on the results of coronary angiography, all patients were divided into two groups according to the Gensini scores: the low-score group (N = 142) and the high-score group (N = 77). The NLR was computed from the ratio of neutrophils and lymphocytes from the complete blood count. The association between the NLR and severity of coronary artery disease was assessed using correlation analysis and logistic regression. The NLR was higher in ACS patients than in SAP and CAC patients (P < 0.05). In addition, the NLR was higher in the high-score group than in the low-score group (P < 0.05). Correlation analysis showed that the NLR was significantly correlated with the Gensini score. After multivariate analysis, high NLRs were independent predictors of high Gensini scores, together with age and high-density lipoprotein. A cutoff NLR of 2.385 predicted high Gensini scores with a sensitivity and specificity of 64 and 63%, respectively. The study suggests that the NLR is an independent predictor of coronary heart disease that may be useful for predicting the severity of coronary artery stenosis.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）与冠状动脉狭窄严重程度之间的关系。共有219例患者纳入本研究，包括51例冠状动脉粥样硬化（CAC）患者、92例稳定型心绞痛（SAP）患者和76例急性冠状动脉综合征（ACS）患者。根据冠状动脉造影结果，所有患者根据Gensini评分分为两组：低分险组（N = 142）和高风险组（N = 77）。NLR通过全血细胞计数中中性粒细胞与淋巴细胞的比值计算得出。采用相关性分析和逻辑回归评估NLR与冠状动脉疾病严重程度之间的关联。ACS患者的NLR高于SAP和CAC患者（P < 0.05）。此外，高风险组的NLR高于低风险组（P < 0.05）。相关性分析表明，NLR与Gensini评分显著相关。多因素分析后，高NLR是高Gensini评分的独立预测因素，与年龄和高密度脂蛋白共同作用。NLR临界值为2.385时预测高Gensini评分的敏感度和特异度分别为64%和63%。该研究表明，NLR是冠心病的独立预测因素，可能有助于预测冠状动脉狭窄的严重程度。
