Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, Republic of Korea.
Chem Asian J. 2013 Apr;8(4):765-70. doi: 10.1002/asia.201201050. Epub 2013 Jan 23.
Monodisperse hollow carbon nanocapsules (<200 nm) with mesoporous shells were synthesized by coating their outer shells with silica to prevent aggregation during their high-temperature annealing. Monodispersed silica nanoparticles were used as starting materials and octadecyltrimethoxysilane (C18TMS) was used as a carbon source to create core-shell nanostructures. These core-shell nanoparticles were coated with silica on their outer shell to form a second shell layer. This outer silica shell prevented aggregation during calcination. The samples were characterized by TEM, SEM, dynamic light scattering (DLS), UV/Vis spectroscopy, and by using the Brunauer-Emmett-Teller (BET) method. The as-synthesized hollow carbon nanoparticles exhibited a high surface area (1123 m(2) g(-1)) and formed stable dispersions in water after the pegylation process. The drug-loading and drug-release properties of these hollow carbon nanocapsules were also investigated.
单分散空心碳纳米胶囊（<200nm）具有介孔壳，通过在其高温退火过程中用二氧化硅涂覆其外壳来防止聚集。单分散二氧化硅纳米粒子被用作起始材料，十八烷基三甲氧基硅烷（C18TMS）被用作碳源来制造核壳纳米结构。这些核壳纳米粒子在其外壳上涂覆有二氧化硅以形成第二层壳。该外层二氧化硅壳在煅烧过程中防止聚集。通过 TEM、SEM、动态光散射（DLS）、UV/Vis 光谱和 Brunauer-Emmett-Teller（BET）方法对样品进行了表征。合成的空心碳纳米粒子表现出高的比表面积（1123m2/g），并且在经过 PEG 化过程后在水中形成稳定的分散体。还研究了这些空心碳纳米胶囊的载药和释药性能。
