Department of Chemistry and Shanghai Key Lab of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and Advanced Materials Laboratory, Fudan University, Shanghai 200433 (P.R. China).
Angew Chem Int Ed Engl. 2014 May 19;53(21):5366-70. doi: 10.1002/anie.201402002. Epub 2014 Apr 24.
Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core-shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual-ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug-resistant strains.
单分散介孔酚醛聚合物纳米球，其直径均匀，被用作进一步生长核壳介孔纳米笼的核。分级介孔纳米球具有均匀的 200nm 直径和 3.1nm 和 5.8nm 的双阶介孔。疏水性碳核的分级介孔结构和两亲性以及亲水性二氧化硅壳赋予其独特的优势，可用于顺铂和紫杉醇联合多药治疗人卵巢癌，甚至是耐药株。
