Liu Yiyao, Miyoshi Hirokazu, Nakamura Michihiro
School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, PR China.
Colloids Surf B Biointerfaces. 2007 Aug 1;58(2):180-7. doi: 10.1016/j.colsurfb.2007.03.005. Epub 2007 Mar 12.
Core-shell nanoparticles of Au@silica with a diameter of approximate 45-60 nm and wall thickness in range of 3-10 nm were synthesized by using 40 and 50 nm gold nanoparticles as the templates. The mesoporous particles are regulated by 3-aminopropyltrimethoxysilane addition. Hollow mesoporous silica nanocapsules (HMSNs) were prepared by using sodium cyanide to dissolve the gold cores. The characterization of Au@silica and HMSNs by transmission electronic microscope indicated that the silica shells were uniform and smooth, and also the porosity was proved by fluorescein isothiocyanate (FITC) release experiments. The ratio of hollow core to HMSNs is more than 70%. HMSNs were subsequently used as drug carrier to investigate FITC (as a model drug) release behaviors in vitro. Fluorescent spectrometry was performed to determine the release kinetics from the HMSNs. The release profiles are significantly different as compared with the control (free FITC), which show that HMSNs are good drug carriers to control drug release, and have high potential in therapeutic drugs delivery in future applications.
以直径约45 - 60纳米、壁厚在3 - 10纳米范围内的Au@二氧化硅核壳纳米颗粒为研究对象，该颗粒通过使用40和50纳米的金纳米颗粒作为模板合成。介孔颗粒通过添加3 - 氨丙基三甲氧基硅烷进行调控。通过使用氰化钠溶解金核制备中空介孔二氧化硅纳米胶囊（HMSNs）。透射电子显微镜对Au@二氧化硅和HMSNs的表征表明，二氧化硅壳层均匀且光滑，异硫氰酸荧光素（FITC）释放实验也证明了其孔隙率。中空核与HMSNs的比例超过70%。随后将HMSNs用作药物载体，研究FITC（作为模型药物）的体外释放行为。采用荧光光谱法测定HMSNs的释放动力学。与对照（游离FITC）相比，释放曲线有显著差异，这表明HMSNs是控制药物释放的良好药物载体，在未来治疗药物递送中具有很高的潜力。
