Department of Chemistry and Medical Chemistry, Yonsei University, Wounju, 220-710, South Korea.
Chemistry. 2013 Mar 25;19(13):4217-22. doi: 10.1002/chem.201201031. Epub 2013 Jan 23.
Iron oxide nanoparticles as contrast agents are reported to effectively improve magnetic resonance imaging of tissues and cells. In this work, cleaved iron oxide nanoparticles (CIONPs) were generated from hydrophobic FeO nanoparticles (HIONPs) by coating their surfaces with PEG-phospholipids, oxidizing them under water, and slowly removing the residual FeO phase in phthalate buffer. The synthesized CIONPs showed good r2 values of up to 258 s(-1) mM(-1). Thus, the CIONPs can be employed as vectors for drug delivery due to their unique structure with an empty inner space, which enables their use in a wide range of applications.
氧化铁纳米颗粒作为对比剂，据报道能有效地提高组织和细胞的磁共振成像效果。在这项工作中，通过用聚乙二醇磷脂包裹疏水性 FeO 纳米颗粒（HIONPs）的表面，将其氧化，并在邻苯二甲酸盐缓冲液中缓慢去除残留的 FeO 相，从而生成了可切割的氧化铁纳米颗粒（CIONPs）。所合成的 CIONPs 表现出高达 258 s(-1) mM(-1)的良好 r2 值。因此，由于其具有内部有空腔的独特结构，CIONPs 可用作药物输送载体，使其能够在广泛的应用中使用。
