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热注入法合成铁/氧化铁核壳纳米粒子用于磁共振成像的 T2 对比增强。

Hot-injection synthesis of iron/iron oxide core/shell nanoparticles for T2 contrast enhancement in magnetic resonance imaging.

机构信息

School of Chemical and Physical Sciences and The MacDiarmid Institute of Advanced Materials and Nanotechnology, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.

出版信息

Chem Commun (Camb). 2011 Aug 28;47(32):9221-3. doi: 10.1039/c1cc13416g. Epub 2011 Jul 15.

DOI:10.1039/c1cc13416g
PMID:21761066
Abstract

Here we report a new, bench-top synthesis for iron/iron oxide core/shell nanoparticles via the thermal decomposition of Fe(η(5)-C(6)H(3)Me(4))(2). The iron/iron oxide core/shell nanoparticles are superparamagnetic at room temperature and show improved negative contrast in T(2)-weighted MR imaging compared to pure iron oxides nanoparticles, and have a transverse relaxivity (r(2)) of 332 mM(-1) s(-1).

摘要

我们在此报告了一种新的铁/氧化铁核/壳纳米粒子的台式合成方法，通过热分解 Fe(η(5)-C(6)H(3)Me(4))(2) 来实现。室温下，铁/氧化铁核/壳纳米粒子具有超顺磁性，与纯氧化铁纳米粒子相比，在 T(2)加权磁共振成像中显示出更好的负对比效果，横向弛豫率（r(2)）为 332 mM(-1) s(-1)。

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