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从慢性化脓性中耳炎患者中分离到一株过氧化氢酶阴性的路邓葡萄球菌,其过氧化氢酶基因有一个新的点突变。

Catalase-negative Staphylococcus lugdunensis strain with a novel point mutation in the catalase gene isolated from a patient with chronic suppurative otitis media.

机构信息

Laboratory Medicine Center, Yinzhou People's Hospital, Ningbo, China.

出版信息

J Clin Microbiol. 2013 Apr;51(4):1310-2. doi: 10.1128/JCM.02879-12. Epub 2013 Jan 23.

DOI:10.1128/JCM.02879-12
PMID:23345293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3666807/
Abstract

This report describes the results of the sequence analysis of a methicillin-susceptible strain of catalase-negative Staphylococcus lugdunensis. Molecular characterization of the deduced sequence revealed a novel point mutation in the catalase gene. To our knowledge, this is the first report of a catalase-negative S. lugdunensis strain, although catalase-negative isolates of Staphylococcus aureus and Staphylococcus epidermidis have been previously reported.

摘要

本报告描述了对一株耐甲氧西林、过氧化氢酶阴性的路邓葡萄球菌的序列分析结果。对推导序列的分子特征分析揭示了过氧化氢酶基因的一个新的点突变。据我们所知,这是首例过氧化氢酶阴性的路邓葡萄球菌菌株的报告,尽管此前已经报道过耐甲氧西林的金黄色葡萄球菌和表皮葡萄球菌的过氧化氢酶阴性分离株。

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Catalase-negative Staphylococcus lugdunensis strain with a novel point mutation in the catalase gene isolated from a patient with chronic suppurative otitis media.从慢性化脓性中耳炎患者中分离到一株过氧化氢酶阴性的路邓葡萄球菌,其过氧化氢酶基因有一个新的点突变。
J Clin Microbiol. 2013 Apr;51(4):1310-2. doi: 10.1128/JCM.02879-12. Epub 2013 Jan 23.
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Catalase-negative Staphylococcus aureus strain with point mutations in the katA gene.在katA基因中存在点突变的过氧化氢酶阴性金黄色葡萄球菌菌株。
J Clin Microbiol. 2008 Jun;46(6):2060-1. doi: 10.1128/JCM.02300-07. Epub 2008 Apr 2.
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VISLISI trial, a prospective clinical study allowing identification of a new metalloprotease and putative virulence factor from Staphylococcus lugdunensis.VISLISI 试验,一项前瞻性临床研究,可从路邓葡萄球菌中鉴定一种新的金属蛋白酶和潜在的毒力因子。
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本文引用的文献

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Application of the antibiotic batumin for accurate and rapid identification of staphylococcal small colony variants.抗生素巴图霉素在准确快速鉴定葡萄球菌小菌落变异体中的应用。
BMC Res Notes. 2012 Jul 24;5:374. doi: 10.1186/1756-0500-5-374.
2
Catalase-negative Staphylococcus aureus isolated from a diabetic foot ulcer.从糖尿病足溃疡中分离出的过氧化氢酶阴性金黄色葡萄球菌。
Iran J Microbiol. 2010 Sep;2(3):165-7.
3
Recovery of a catalase-negative Staphylococcus epidermidis strain in blood and urine cultures from a patient with pyelonephritis.从肾盂肾炎患者的血液和尿液培养物中恢复出一株过氧化氢酶阴性表皮葡萄球菌。
J Clin Microbiol. 2011 Nov;49(11):4018-9. doi: 10.1128/JCM.01031-11. Epub 2011 Sep 7.
4
Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus Strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene.从一位患有二尖瓣心内膜炎和心包炎的患者中分离到一株过氧化氢酶阴性金黄色葡萄球菌亚种金黄色葡萄球菌,对其进行分子特征分析发现 katA 基因的一个新的无义突变。
J Clin Microbiol. 2011 Sep;49(9):3398-402. doi: 10.1128/JCM.00849-11. Epub 2011 Jun 29.
5
Acute necrotizing sinusitis caused by Staphylococcus lugdunensis.金黄色葡萄球菌引起的急性坏死性鼻窦炎。
J Clin Microbiol. 2011 Jul;49(7):2740-2. doi: 10.1128/JCM.00722-11. Epub 2011 May 18.
6
Staphylococcus lugdunensis native tricuspid valve endocarditis: a case report and review of literature.中文译文:土生金黄色酿脓葡萄球菌三尖瓣心内膜炎:病例报告及文献复习。
J Gen Intern Med. 2011 Oct;26(10):1209-11. doi: 10.1007/s11606-011-1718-5. Epub 2011 May 3.
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Staphylococcus lugdunensis infective endocarditis: a literature review and analysis of risk factors.金黄色葡萄球菌感染性心内膜炎:文献回顾与危险因素分析。
J Microbiol Immunol Infect. 2010 Dec;43(6):478-84. doi: 10.1016/S1684-1182(10)60074-6.
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Laboratory and clinical characteristics of Staphylococcus lugdunensis prosthetic joint infections.金黄色葡萄球菌人工关节感染的实验室和临床特征。
J Clin Microbiol. 2010 May;48(5):1600-3. doi: 10.1128/JCM.01769-09. Epub 2010 Feb 24.
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Staphylococcal catalase protects intracellularly survived bacteria by destroying H2O2 produced by the murine peritoneal macrophages.葡萄球菌过氧化氢酶通过破坏小鼠腹膜巨噬细胞产生的过氧化氢来保护细胞内存活的细菌。
Microb Pathog. 2009 Aug;47(2):57-67. doi: 10.1016/j.micpath.2009.04.012. Epub 2009 May 9.
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Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community.路邓葡萄球菌,社区皮肤和软组织感染的常见病因。
J Clin Microbiol. 2009 Apr;47(4):946-50. doi: 10.1128/JCM.01024-08. Epub 2009 Feb 25.