Guo C, Levine H
Dept. of Physics, University of California San Diego, La Jolla, CA 92093-0319 U.S.A.
J Biol Phys. 2000 Sep;26(3):219-34. doi: 10.1023/A:1010313529687.
We introduce and study a simple lattice statistical mechanics modelfor the clustering of tumor necrosis factor receptor I (TNFR1).Our model explains clustering under over-expression of the cytoplasmicsignal transducer as well as the clustering induced via extracellularligand binding; also we explain why the loss of transducer leads to arapid break-up of the clusters. The basic mechanism at work is a first-order(cooperative) phase transition caused by the multimeric binding capability ofthe receptor-transducer complex. Using cooperativity of this type, the cellsare found to have an enhanced sensitivity and robustness. In general, ourmethod can be applied to other receptor-clustering related signaling system.
我们引入并研究了一种用于肿瘤坏死因子受体I（TNFR1）聚集的简单晶格统计力学模型。我们的模型解释了细胞质信号转导器过表达时的聚集以及细胞外配体结合诱导的聚集；此外，我们还解释了为什么转导器的缺失会导致聚集体迅速解体。起作用的基本机制是由受体 - 转导器复合物的多聚体结合能力引起的一级（协同）相变。利用这种类型的协同作用，发现细胞具有更高的敏感性和鲁棒性。一般来说，我们的方法可以应用于其他与受体聚集相关的信号系统。
