Baras T, Kleine-Ostmann T, Koch M
Institut für Hochfrequenztechnik, Technische Universität Braunschweig Schleinitzstrasse, 22 -, 38106 Braunschweig, Germany.
J Biol Phys. 2003 Jun;29(2-3):187-94. doi: 10.1023/A:1024444809852.
The marker-free on-chip distinction betweenhybridised (double-stranded) DNA (HDNA) anddenatured (single-stranded) DNA (DDNA) hasrecently been demonstrated using ultrashortelectrical pulses. The electrical THzpulses propagate in integrated waveguidesincorporating resonant THz structures ontowhich the genetic material is deposited.For a possible future realisation of a highthroughput array, it is crucial to optimizethe experimental parameters and theresonant structure. In this paper weperform a first numerical study ofdifferent resonator geometries and examinethe influence of critical experimentalparameters on the transmissioncharacteristics of the resonant structures.Our simulations demonstrate that the ringresonator shows a comparable performance tothe parallel-coupled resonator previouslyused in a first demonstration by Nagel andcoworkers.
最近，利用超短电脉冲实现了杂交（双链）DNA（HDNA）和变性（单链）DNA（DDNA）在芯片上的无标记区分。电太赫兹脉冲在集成波导中传播，该波导包含沉积有遗传物质的共振太赫兹结构。对于未来高通量阵列的可能实现，优化实验参数和共振结构至关重要。在本文中，我们对不同的谐振器几何形状进行了首次数值研究，并研究了关键实验参数对共振结构传输特性的影响。我们的模拟表明，环形谐振器的性能与Nagel及其同事在首次演示中使用的平行耦合谐振器相当。
