离子通道物理学
Physics of ion channels.
作者信息
Kuyucak Serdar, Bastug Turgut
机构信息
Department of Theoretical Physics, Research School of Physical Sciences, Australian National University, Canberra, ACT 0200 Australia.
出版信息
J Biol Phys. 2003 Dec;29(4):429-46. doi: 10.1023/A:1027309113522.
Abstract
We review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical approaches. Application of Brownian and molecular dynamics methods to channels with known molecular structures is discussed.
摘要
我们回顾了离子跨细胞中膜通道运输所涉及的基础物理学。从微观和宏观角度讨论了控制离子扩散的电化学力。提出了将布朗动力学用作最小唯象模型的理由，该模型为实验与更基础的理论方法之间架起了一座桥梁。还讨论了布朗动力学和分子动力学方法在具有已知分子结构的通道中的应用。
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本文引用的文献
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Theoretical and computational models of ion channels.离子通道的理论与计算模型
Curr Opin Struct Biol. 2002 Apr;12(2):182-9. doi: 10.1016/s0959-440x(02)00307-x.
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Reservoir boundaries in Brownian dynamics simulations of ion channels.离子通道布朗动力学模拟中的储库边界
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