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[急性白血病中环磷酸腺苷浓度的预后意义]

[Prognostic significance of the cyclic AMP concentration in acute leukemias].

作者信息

Paietta E, Mittermayer K, Schwarzmeier J D

出版信息

Acta Med Austriaca. 1979;6(5):231-3.

PMID:233459
Abstract

In patients with acute leukemia (myeloblastic, lymphoblastic, undifferentiated) proliferation kinetics and cyclic adenosine-3', 5'-monophosphate (cAMP) concentration of the leukemic cells were studied for their significance in the prediction of responsiveness to cytostatic therapy. Patients with good clinical response had significantly faster turnover and lower cAMP-levels than those who failed to respond to treatment.

摘要

在急性白血病(髓母细胞性、淋巴细胞性、未分化型)患者中,研究了白血病细胞的增殖动力学和环磷腺苷(cAMP)浓度,以探讨其在预测细胞抑制疗法反应性方面的意义。临床反应良好的患者,其白血病细胞更新速度明显更快,且cAMP水平更低,而治疗无效的患者则不然。

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