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特发性肺纤维化中纤维增生性愈合的生物标志物

Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias.

作者信息

Vasakova Martina, Sterclova Martina, Stranska Eliska, Mandakova Petra, Skibova Jelena, Matej Radoslav

机构信息

Department of Respiratory Medicine, Thomayer Hospital, Videnska 800, 14059 Prague 4, Czech Republic.

出版信息

Open Respir Med J. 2012;6:160-4. doi: 10.2174/1874306401206010160. Epub 2012 Dec 28.

DOI:10.2174/1874306401206010160
PMID:23346263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3551240/
Abstract

AIMS

The main feature of fibrosing idiopathic interstitial pneumonias (fIIPs) is the fibroproliferative potential of underlying pathogenetic process. We hypothesize that the concentration of potential markers of fibroproliferative healing, PAR-2, TGF-β1, TNF-α and IL-4Rα in bronchoalveolar lavage fluid (BALF) differ in patients with fIIPs compared to controls (C).

PATIENTS AND METHODS

10 patients with fIIPs and 9 controls (C) were included to the study. Concentrations of CD124 (IL4Rα), PAR-2, TGF-β1 and TNF-α in BALF were determined using the ELISA method.

RESULTS

We observed higher concentrations of IL4Rα (fIIPS 1499.4 pg/ml vs C 255.5 pg/ml; p < 0.05), PAR-2 (fIIPS 1807.9 pg/ml vs C 421.0 pg/ml; p < 0.05) and TGF-β1(fIIPS 283.0 pg/ml vs C 197.1 pg/ml; p < 0.01) in BALF in fIIPs versus C. The values of TNF-a in BALF did not differ significantly in fIIPs compared to controls. The ratios also showed differences in fIIPS and C: IL4Rα/TGF-β1 (fIIPS 6.19 vs C 0.68; p = 0.0143); TNF-α/IL4Rα (fIIPS 0.84 vs C 7.93; p = 0.043); TGF-β1/TNF-α (fIIPS 0.21 vs C 0.16; p = 0.0179) and protein/PAR-2 (fIIPS 0.06 vs C 0.28; p = 0.0033).

CONCLUSIONS

We found that PAR-2, TGF-β1 and IL-4Rα are significantly up-regulated in the BALF of fIIPs compared to controls, therefore we suppose they could become biomarkers of fibroproliferative healing.

摘要

目的

纤维化性特发性间质性肺炎（fIIPs）的主要特征是潜在致病过程的纤维增殖潜能。我们假设，与对照组（C）相比，fIIPs患者支气管肺泡灌洗液（BALF）中纤维增殖愈合潜在标志物PAR-2、TGF-β1、TNF-α和IL-4Rα的浓度存在差异。

患者与方法

10例fIIPs患者和9例对照（C）纳入本研究。采用ELISA法测定BALF中CD124（IL4Rα）、PAR-2、TGF-β1和TNF-α的浓度。

结果

我们观察到，与对照组相比，fIIPs患者BALF中IL4Rα（fIIPs组为1499.4 pg/ml，C组为255.5 pg/ml；p<0.05）、PAR-2（fIIPs组为1807.9 pg/ml，C组为421.0 pg/ml；p<0.05）和TGF-β1（fIIPs组为283.0 pg/ml，C组为197.1 pg/ml；p<0.01）的浓度较高。与对照组相比，fIIPs患者BALF中TNF-α的值无显著差异。fIIPs组与C组的比值也存在差异：IL4Rα/TGF-β1（fIIPs组为6.19，C组为0.68；p = 0.0143）；TNF-α/IL4Rα（fIIPs组为0.84，C组为7.93；p = 0.043）；TGF-β1/TNF-α（fIIPs组为0.21，C组为0.16；p = 0.0179）以及蛋白/PAR-2（fIIPs组为0.06，C组为0.28；p = 0.0033）。

结论

我们发现，与对照组相比，fIIPs患者BALF中PAR-2、TGF-β1和IL-4Rα显著上调，因此我们推测它们可能成为纤维增殖愈合的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c1/3551240/9c41ef7ff2c0/TORMJ-6-160_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c1/3551240/e5e5d7299a72/TORMJ-6-160_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c1/3551240/9c41ef7ff2c0/TORMJ-6-160_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c1/3551240/e5e5d7299a72/TORMJ-6-160_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c1/3551240/9c41ef7ff2c0/TORMJ-6-160_F2.jpg

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