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蒲公英和路易波士提取物复合物 CRS-10 改善中老年男性雄性激素缺乏症症状。

Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male.

机构信息

Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.

出版信息

Nutr Res Pract. 2012 Dec;6(6):505-12. doi: 10.4162/nrp.2012.6.6.505. Epub 2012 Dec 31.

DOI:10.4162/nrp.2012.6.6.505
PMID:23346300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3542440/
Abstract

Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males' Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.

摘要

许多老年男性患有各种更年期症状，包括体力和脑力活动的丧失。本研究评估了 CRS-10 蒲公英和南非博士茶提取物复合物（CRS-10）对更年期症状的潜在缓解作用。根据典型的生理应激，测量了 CRS-10 处理的 TM3 睾丸间质细胞（TM3 细胞）的存活率。在每天摄入 CRS-10 4 周后，测量了老年大鼠（18 周）的睾丸激素水平、体力活动以及精子的数量和活力。此外，在摄入 400 毫克 CRS-10 后，对 30 名男性进行了 AMS（男性衰老症状）问卷调查。总的来说，CRS-10 通过激活 ERK 和 Akt 通路，保护 TM3 细胞免受血清限制和氧化应激的影响。大鼠睾丸激素水平和精子发生的激活显著增强。此外，体力活动明显改善。根据使用 AMS 的临床调查，每日摄入 400 毫克 CRS-10 可提高老年男性受访者的生活质量。这些结果表明，CRS-10 作为一种安全有效的天然物质，具有减轻或缓解更年期症状的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/f3356f65e015/nrp-6-505-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/0b6cc65b4f92/nrp-6-505-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/d4372ea0b63e/nrp-6-505-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/32bfbf964d44/nrp-6-505-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/7f93ecce91d3/nrp-6-505-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/dcf3b33982d9/nrp-6-505-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/f3356f65e015/nrp-6-505-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/0b6cc65b4f92/nrp-6-505-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/cff7215eb78e/nrp-6-505-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/d4372ea0b63e/nrp-6-505-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/32bfbf964d44/nrp-6-505-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/dcf3b33982d9/nrp-6-505-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8410/3542440/f3356f65e015/nrp-6-505-g007.jpg

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