孕期、子痫前期和子痫中的肾素-血管紧张素系统（RAS）
RAS in Pregnancy and Preeclampsia and Eclampsia.
作者信息
Rodriguez M, Moreno J, Hasbun J
机构信息
Department of Obstetrics and Gynecology, Universidad de Valparaiso, 2341131 Valparaiso, Chile ; Fetal Medicine Unit, Hospital Carlos Van Buren, 2341131 Valparaiso, Chile.
出版信息
Int J Hypertens. 2012;2012:739274. doi: 10.1155/2012/739274. Epub 2012 Dec 30.
Abstract
Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS), which would have an important role in the origin of multisystem involvement. This paper reviews the evidence supporting the involvement of RAS in triggering the disease, in addition to the components of this system that would be involved and how it eventually produces brain engagement.
摘要
子痫前期是一种常见的妊娠疾病，其特征为高血压以及继发于全身性内皮功能障碍的包括脑在内的多个器官受累。其病因尚不完全清楚，但涉及多种因素，其中肾素-血管紧张素系统（RAS）尤为突出，该系统在多系统受累的发病机制中可能起重要作用。本文综述了支持RAS参与引发该疾病的证据，以及该系统中可能涉及的组成部分，及其最终导致脑部受累的机制。
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