Chen Quan, Yang Ridong, Gao Aili, Zhong Daoqing, Zhu Huilan
Guangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
Exp Ther Med. 2017 Jul;14(1):131-134. doi: 10.3892/etm.2017.4445. Epub 2017 May 9.
The objective of the present study was to investigate the clinical efficacy of high-frequency fulguration combined with 5% imiquimod cream for condyloma acuminatum (CA), and the effect on T cell immune function and serum levels of interleukin (IL)-2 and IL-10. We enrolled 112 patients with CA between January 2014 and January 2016. Patients were randomly divided into the control group (n=56) and observation group (n=56). The control group received high-frequency fulguration combined with intramuscular injection of Bacillus Calmette-Guérin polysaccharide nucleic acid, and the observation group received high-frequency fulguration combined with external application of 5% imiquimod cream. In both groups, the course of treatment lasted for 12 weeks, and the follow-up period was 6 months. Clinical efficacy was compared between the groups. The total effective rate in the observation group was higher than that in the control group (p<0.05), but no significant differences were identified in comparisons of effectiveness and recurrence rate between the two groups (p>0.05). After treatment, the levels of CD3 and CD4 cells, and CD4/CD8 ratio in both groups were increased compared with those before treatment (p<0.05), while no significant difference was identified in comparison of the levels of CD8 cells in both groups before and after treatment (p>0.05); in both groups before and after treatment, there was no significant difference in the comparison of T cells (p>0.05). After treatment in both groups, the serum levels of IL-2 were increased, and the levels of IL-10 were decreased compared with those before treatment; the improvement in the observation group was superior to that in the control group (p<0.05). In conclusion, good efficacy can be achieved with the combined treatment of high-frequency fulguration and 5% imiquimod cream for CA, which is correlated with enhanced immune functions of T cells, and improvements in the serum levels of IL-2 and IL-10.
本研究的目的是探讨高频电灼联合5%咪喹莫特乳膏治疗尖锐湿疣（CA）的临床疗效，以及对T细胞免疫功能和血清白细胞介素（IL）-2、IL-10水平的影响。我们纳入了2014年1月至2016年1月期间的112例CA患者。患者被随机分为对照组（n = 56）和观察组（n = 56）。对照组接受高频电灼联合肌内注射卡介菌多糖核酸，观察组接受高频电灼联合外用5%咪喹莫特乳膏。两组治疗疗程均为12周，随访期为6个月。比较两组的临床疗效。观察组的总有效率高于对照组（p<0.05），但两组在疗效和复发率比较上无显著差异（p>0.05）。治疗后，两组CD3、CD4细胞水平及CD4/CD8比值均较治疗前升高（p<0.05），而两组治疗前后CD8细胞水平比较无显著差异（p>0.05）；两组治疗前后T细胞比较无显著差异（p>0.05）。两组治疗后血清IL-2水平升高，IL-10水平降低；观察组的改善情况优于对照组（p<0.05）。综上所述，高频电灼联合5%咪喹莫特乳膏治疗CA疗效良好，这与T细胞免疫功能增强以及血清IL-2、IL-10水平改善有关。
