Wu Guoqiang, Wang Xiaochen, Zhang Xuefeng
1 Department of General Surgery, The General Hospital of ShenYang Military Area Command , Shenyang, China .
Cancer Biother Radiopharm. 2013 May;28(4):298-302. doi: 10.1089/cbr.2012.1374. Epub 2013 Jan 24.
To investigate the expression status of periostin in colorectal cancer (CRC) to lay a foundation for managing this disease.
Periostin expression status was detected by immunohistochemistry staining in 720 CRC specimens. The relationship between the periostin protein and clinicopathological factors and prognosis was subsequently determined.
The periostin protein was expressed significantly higher in CD133+ tumor cells compared to CD133- tumor cells. Positively expressed periostin was observed in 218 (30.28%) of the 720 cases. Spearman correlation analysis showed that periostin expression has a linear correlation to the tumor size, histological type, lymph node metastasis, TNM stage, and postoperative liver metastasis (p=0.02, 0.035, 0.001, 0.001, and 0.001, respectively). Multivariate analysis showed that histological type, lymph node metastasis, TNM stage, and periostin were found to be related to liver metastasis (p=0.01, 0.035, 0.01, and 0.001, respectively). In the Cox regression test, the histological grade, Lymph node metastasis, TNM stage, and periostin were detected as independent prognostic factors (p=0.01, 0.001, 0.001, and 0.001, respectively).
Periostin was found to be related to the liver metastasis of CRC and may be a potential target for CRC.
研究骨膜蛋白在结直肠癌（CRC）中的表达状况，为该疾病的治疗奠定基础。
采用免疫组织化学染色法检测720例CRC标本中骨膜蛋白的表达状况。随后确定骨膜蛋白与临床病理因素及预后之间的关系。
与CD133-肿瘤细胞相比，CD133+肿瘤细胞中骨膜蛋白的表达显著更高。在720例病例中，有218例（30.28%）观察到骨膜蛋白呈阳性表达。Spearman相关性分析表明，骨膜蛋白表达与肿瘤大小、组织学类型、淋巴结转移、TNM分期及术后肝转移呈线性相关（p值分别为0.02、0.035、0.001、0.001和0.001）。多因素分析表明，组织学类型、淋巴结转移、TNM分期及骨膜蛋白与肝转移有关（p值分别为0.01、0.035、0.01和0.001）。在Cox回归检验中，组织学分级、淋巴结转移、TNM分期及骨膜蛋白被检测为独立的预后因素（p值分别为0.01、0.001、0.001和0.001）。
发现骨膜蛋白与CRC的肝转移有关，可能是CRC的一个潜在靶点。
