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骨膜蛋白在结直肠癌中的预后意义。

Prognostic significance of periostin in colorectal cancer.

作者信息

Deng Xingming, Ao Sheng, Hou Jianing, Li Zhuofei, Lei Yunpeng, Lyu Guoqing

机构信息

Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.

出版信息

Chin J Cancer Res. 2019 Jun;31(3):547-556. doi: 10.21147/j.issn.1000-9604.2019.03.16.

DOI:10.21147/j.issn.1000-9604.2019.03.16
PMID:31354223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6613499/
Abstract

Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC.

摘要

越来越多的证据表明，骨膜蛋白在组织损伤、炎症、纤维化和肿瘤进展中经常上调。癌细胞中骨膜蛋白的表达可通过激活PI3K/Akt信号通路促进结直肠癌（CRC）的转移潜能。此外，骨膜蛋白主要在肿瘤基质和癌细胞的细胞质中观察到，这可能促进CRC的侵袭性。在这篇综述中，我们总结了有关骨膜蛋白的信息，以强调其作为CRC预后标志物的作用。

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Chin J Cancer Res. 2019 Jun;31(3):547-556. doi: 10.21147/j.issn.1000-9604.2019.03.16.
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本文引用的文献

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Identification of Serum Periostin as a Potential Diagnostic and Prognostic Marker for Colorectal Cancer.血清骨膜蛋白作为结直肠癌潜在诊断和预后标志物的鉴定
Clin Lab. 2018 Jun 1;64(6):973-981. doi: 10.7754/Clin.Lab.2018.171225.
2
Individualized prediction of perineural invasion in colorectal cancer: development and validation of a radiomics prediction model.结直肠癌中神经周围侵犯的个体化预测：一种影像组学预测模型的开发与验证
Chin J Cancer Res. 2018 Feb;30(1):40-50. doi: 10.21147/j.issn.1000-9604.2018.01.05.
3
Increased expression of the stromal fibroblast-secreted periostin in canine squamous cell carcinomas.犬鳞状细胞癌中基质成纤维细胞分泌的骨膜蛋白表达增加。
J Vet Med Sci. 2018 Mar 24;80(3):473-479. doi: 10.1292/jvms.17-0647. Epub 2018 Feb 6.
4
Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin-mediated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin.骨髓间充质干细胞通过骨膜蛋白介导的磷酸肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白促进头颈癌进展。
Cancer Sci. 2018 Mar;109(3):688-698. doi: 10.1111/cas.13479. Epub 2018 Jan 23.
5
Periostin Expression in Non-Small Cell Lung Cancer: Clinical Significance.骨膜蛋白在非小细胞肺癌中的表达：临床意义
Kurume Med J. 2018 Feb 26;64(1.2):13-20. doi: 10.2739/kurumemedj.MS640012. Epub 2017 Nov 27.
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Oncotarget. 2016 Aug 23;8(52):89552-89565. doi: 10.18632/oncotarget.11533. eCollection 2017 Oct 27.
7
Epithelial periostin expression is correlated with poor survival in patients with invasive breast carcinoma.上皮性骨膜蛋白表达与浸润性乳腺癌患者的不良生存相关。
PLoS One. 2017 Nov 21;12(11):e0187635. doi: 10.1371/journal.pone.0187635. eCollection 2017.
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RETRACTED: Effects of lentivirus-mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer.撤回：慢病毒介导的骨膜蛋白沉默通过整合素信号通路对肺癌肿瘤微环境和骨转移的影响
Life Sci. 2017 Aug 1;182:10-21. doi: 10.1016/j.lfs.2017.05.030. Epub 2017 Jun 7.
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