系统性硬皮病雷诺现象的治疗。

Treatment of Raynaud phenomenon in systemic sclerosis.

机构信息

Department of Rheumatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.

出版信息

Intern Med J. 2013 May;43(5):476-83. doi: 10.1111/imj.12082.

DOI:10.1111/imj.12082

Abstract

Systemic sclerosis is a connective tissue disease characterised by microvascular injury and excessive fibrosis of the skin and internal organs. Most patients with this condition experience Raynaud phenomenon, usually as the earliest manifestation of disease. In addition to pain and functional impairment, Raynaud phenomenon can produce tissue ischaemia resulting in digital ulceration and gangrene. Current treatments have been only moderately successful in reducing the frequency and severity of Raynaud phenomenon in patients with systemic sclerosis. This review will address treatments available for Raynaud phenomenon in systemic sclerosis.

摘要

系统性硬化症是一种结缔组织疾病，其特征为微血管损伤和皮肤及内脏器官的过度纤维化。大多数此类病症患者会出现雷诺现象，通常为疾病的最早表现。除疼痛和功能障碍外，雷诺现象还可导致组织缺血，从而引起指端溃疡和坏疽。目前的治疗方法仅能在一定程度上减少系统性硬化症患者雷诺现象的发作频率和严重程度。本文将对系统性硬化症中雷诺现象的治疗方法进行综述。