Dong Liping, Wang Haoran, Wang Dao Wen, Ding Hu
Department of Nephrology Puai Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China.
Ann Hum Genet. 2013 May;77(3):183-90. doi: 10.1111/ahg.12010. Epub 2013 Jan 24.
Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta-analysis was assessed by STATA 9.2. Twenty-one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.25-1.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.
我们的目的是评估9p21基因座中的单核苷酸多态性（SNPs）对东亚人群冠心病遗传易感性的影响。我们在PubMed、EMBASE和中国知网中检索了与东亚人群9p21基因座内SNPs与冠心病关联相关的文献。本荟萃分析采用STATA 9.2进行评估。荟萃分析纳入了15篇合格论文中的21项研究，共25945例病例和31777例对照。风险等位基因的比值比（OR）和95%置信区间（CI）为1.30（1.25 - 1.35），存在中度异质性。本研究未观察到发表偏倚。敏感性分析进一步加强了这种关联的有效性。总之，9p21基因座内的SNPs与东亚人群冠心病风险密切相关，其风险OR与白种人群相似。
