Presence of tolyl-specific IgE and absence of IgG antibodies in workers exposed to toluene diisocyanate.

Independent immunoenzymatic and radioimmunoassay techniques indicated the absence of tolyl-specific IgG antibodies in sera from 25 workers with long-term exposure to toluene diisocyanate (TDI). Five of these workers were clinically hypersensitive to TDI and displayed significant titers of tolyl-specific IgE antibodies in their sera.