Karol M H, Sandberg T, Riley E J, Alarie Y
J Occup Med. 1979 May;21(5):354-8.
Three workers with TDI hypersensitivity were evaluated for IgE antibodies to TDI over a period of 13 months. A radioallergosorbent test (RAST) system was employed using p-toly(mono)isocyanate-human serum albumin antigen covalently bound to cyanogen bromide-activated paper discs. IgE antibody titers were consistently elevated in two individuals who experienced several bronchial hypersensitivity responses to TDI during the study period. The responses were either solely asthmatic or asthmatic accompanied by cutaneous hypersensitivity reactions. By contrast, antibody titers in a third subject who had not experienced any hyersensitivity reactions during the study period continually decreased, falling to insignificant levels after 12 months. In the absence of renewed TDI exposure, sensitive workers may have titers indistinguishable from those of workers exposed to TDI but without sensitivity to the chemical.
在13个月的时间里，对3名患有甲苯二异氰酸酯（TDI）超敏反应的工人进行了TDI IgE抗体评估。采用放射性变应原吸附试验（RAST）系统，使用与溴化氰活化纸片共价结合的对甲苯基（单）异氰酸酯-人血清白蛋白抗原。在研究期间，有两名个体对TDI出现了几次支气管超敏反应，其IgE抗体滴度持续升高。这些反应要么只是哮喘，要么是哮喘伴有皮肤超敏反应。相比之下，第三名受试者在研究期间未经历任何超敏反应，其抗体滴度持续下降，12个月后降至无显著意义的水平。在没有再次接触TDI的情况下，敏感工人的抗体滴度可能与接触TDI但对该化学品不敏感的工人无法区分。
