Department of Dermatology, Medical University of Lublin, Lublin, Poland.
Int J Dermatol. 2013 Feb;52(2):153-62. doi: 10.1111/j.1365-4632.2012.05584.x.
Psoriasis, a systemic inflammatory disease, is associated with enhanced atherosclerosis and risk of cardiovascular (CV) disease, which may account for higher morbidity and mortality rates in psoriatic patients. It especially applies to younger psoriatic patients with more severe disease, reducing their life expectancy. The aim of the study was to review the literature on CV disease in psoriasis as well as the pathogenic mechanisms shared between psoriasis and atherosclerosis. Moreover, case-control and cohort studies published between 2006 and 2011 were selected for meta-analysis. The meta-analysis indicates elevated risk of cardiovascular events in psoriatic patients in relation to non-psoriatic controls (OR 1.28; 95% CI 1.18-1.38). It is suggested that the treatment of the inflammatory processes involved in the pathogenesis of both psoriasis and atherosclerosis may be beneficial in reducing the CV risk in psoriatic patients. Further in-depth investigations, including prospective studies, are needed to enable more effective management of psoriatic patients in the future.
银屑病，一种全身性炎症性疾病，与动脉粥样硬化和心血管（CV）疾病风险增加相关，这可能导致银屑病患者的发病率和死亡率更高。它尤其适用于疾病更严重的年轻银屑病患者，降低了他们的预期寿命。本研究旨在综述银屑病患者的 CV 疾病以及银屑病和动脉粥样硬化之间共同的发病机制的文献。此外，还选择了 2006 年至 2011 年期间发表的病例对照和队列研究进行荟萃分析。荟萃分析表明，与非银屑病对照组相比，银屑病患者发生心血管事件的风险增加（OR 1.28；95% CI 1.18-1.38）。这表明，治疗银屑病和动脉粥样硬化发病机制中涉及的炎症过程可能有助于降低银屑病患者的 CV 风险。需要进一步深入调查，包括前瞻性研究，以便将来能够更有效地管理银屑病患者。
